The treatment of fusospirochetosis with penicillin sodium became apparent after the preliminary report by Mahoney and his co-workers1 in 1943 noting the influence of penicillin therapy on the clinical manifestations and serologic reactions of patients with early syphilis. Also in 1943 Heilman and Herrell2 found penicillin to be effective in experimental animals against other spirochetal infections, namely Leptospira icterohemorrhagiae of Weil's disease, Spirillum minus of rat bite fever and Spirillum recurrentis of relapsing fever. Following the confirmation3 of these studies the use of penicillin against Spirillum vincenti became a reasonable sequence. With the more general use of this chemotherapeutic agent in various bacteriologic infections an apparent relationship between the condition of the gingivae and pharynx with the administration of penicillin was observed by Strock4 and others in 1944. In such cases ulceration and bleeding of the gingivae disappeared after penicillin therapy was instituted, leaving the gums
PEARCE WF, McDONALD JB. TREATMENT OF AMBULATORY PATIENTS WITH PENICILLIN SODIUM: PRELIMINARY STUDIES OF FUSOSPIROCHETOSIS. JAMA. 1945;128(5):342–344. doi:10.1001/jama.1945.02860220024006
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