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December 12, 1936

EXPERIMENTAL EPIDEMIOLOGY

JAMA. 1936;107(24):1971-1972. doi:10.1001/jama.1936.02770500037013
Abstract

The study of experimental epidemics recently reported by Greenwood, Hill, Topley and Wilson1 involves observations extending over some fifteen years and the use of between 100,000 and 200,000 mice. Their methods were adequately controlled and ably presented. In fact, so carefully was their technic developed that it usually proved possible to maintain herds of mice for months or years without the accidental introduction of any extraneous infection.

In one series of observations, six different epidemics of pasteurellosis were under simultaneous observation. In the long continued epidemics under these experimental conditions, no tendency for periods of high or low mortality to recur at definite seasons of the year was noted. Uncontaminated animals were introduced to many of their herds of infected mice at stated intervals. The great majority of such mice were infected shortly after entrance, so that the reacting system at any moment contained a relatively small proportion of

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