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June 2, 1945


JAMA. 1945;128(5):365-366. doi:10.1001/jama.1945.02860220047015

Recent work of American and English investigators has extended our knowledge of the hyaluronic acidhyaluronidase system in several interesting directions of important physiologic, pathologic and therapeutic implications. Hyaluronic acid, previously shown to occur in the vitreous humor, synovial fluid, skin and umbilical cord of various mammals,1 was found also in the lung2 and in tumor tissue of various types.3 Probably hyaluronic acid, free or bound, is a constituent of other cement substances and mucoid matter of mesodermal structures in the body. Its presence may be related to the metachromatic properties of some of these substances, especially such as occur in increasing amounts with progressive age in the walls of large and small arteries. A study of the role of increased capillary permeability to the hyaluronic acid content of capillary structures may yield interesting results.

Recent experiments of Meyer, Hahnel and Feiner4 have shown that solutions of