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December 12, 1936


JAMA. 1936;107(24):1985-1986. doi:10.1001/jama.1936.02770500051023

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To the Editor:—  The advisability of using insoluble bismuth compounds in antisyphilitic treatment is periodically brought up for discussion by medical societies, clinics and individual physicians. A general interest in this matter may justify a summary of my views, which have been given on occasion extemporaneously. My views are based on the results of experimental and clinical studies over a period of years of several bismuth compounds in our department and in the literature. The very extensive data of the literature, including most of ours, may be found in a recent compilation by Forst of Munich, probably the most complete and best, single, up-to-date summary of the pharmacologic and clinical actions of bismuth (Handb. d. exper. Pharmakol.3:2249-2730 [part 4] 1935):The use of insoluble bismuth compounds in antisyphilitic treatment has been considerably favored, although this usage represents a curious contradiction in pharmacologic principles. The inconsistency is impressive when

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