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December 12, 1936

Neuroembryology: An Experimental Study

JAMA. 1936;107(24):1996. doi:10.1001/jama.1936.02770500062032

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Speculation regarding the formative agencies that determine the growth and adult form of the body has been replaced by experimental evidence accumulated during the past fifty years by Roux, Born, Spemann, Harrison and their successors. The agencies that control the processes of growth and differentiation include mechanical, chemical and electrical factors, and the problem is to isolate these and determine the part played by each in the dynamic vital process. This volume reports the facts so far established and the conclusions to which they point. Most of the experiments here summarized were made on amphibians from egg to adult stages by the methods of experimental surgery, with which the author himself has worked so fruitfully. There is a brief history of the neuron concept and the experimental evidence in its support, with an analysis of the parts played by neuroblasts and sheath cells in the development of peripheral nerves, including

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