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June 2, 1945

The Specificity of Serological Reactions

JAMA. 1945;128(5):395. doi:10.1001/jama.1945.02860220077038

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The textual revision was completed before the author's death in June 1943. Much new material has been included. In his preface the author mentions with regret that the most recent European literature, other than British, could not be considered because it was not available. The original plan of the book has been maintained. The first chapters deal with natural antigens and antibodies; then artificial conjugated antigens and the serologic reactivity of simple chemical compounds (including experiments on "drug allergy") are considered; chapters 6 and 7 are devoted to the chemistry of specific nonprotein cell substances and to the consideration of antigen-antibody reactions from a physiochemical approach. The chapter by Linus Pauling on molecular structure and intermolecular forces concludes the text. Every paragraph in this classic book reveals the firm, comprehensive grasp of serologic problems by a great investigator.

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