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June 9, 1945

THIOURACIL IN THYROTOXICOSIS: OBSERVATIONS IN THE TREATMENT OF THIRTY-TWO PATIENTS

JAMA. 1945;128(6):419-423. doi:10.1001/jama.1945.02860230023006
Abstract

In the relatively short period of time since Astwood1 first reported on the action of the thyroid inhibitors, thiourea and thiouracil, numerous reports, generally confirming the original observations, have appeared.2 Most of the experience has been with thiouracil, and few instances of resistance to the drug have been recorded.3 Unfavorable reactions4 have been encountered in approximately 10 per cent of those treated, the most alarming disturbance being agranulocytosis. Despite this obstacle, investigations are continuing and a sizable and revealing clinical experience is gradually being acquired.

In an earlier report in The Journal I5 described the treatment of 9 patients, of whom 6 were improved, 2 stopped treatment too early and 1 failed to respond. The present report deals with a broader series of observations made in the treatment of 32 patients. Fifteen of these, 11 females and 4 males, ranging in age from 16 to

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