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June 16, 1945


JAMA. 1945;128(7):508-509. doi:10.1001/jama.1945.02860240034008

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The treatment of chronic gonorrheal vaginitis has undergone rapid changes in the past few years. Sulfonamide therapy has brought rapid cure of this stubborn disease in the majority of instances. However, since several cases have been found to be sulfonamide resistant, estrogen therapy (diethylstilbestrol) has been recently advocated. With the advent of penicillin, it seems quite evident that this drug is by far the most effective and the safest to use in the therapy of gonorrheal infections.

It is our purpose in this paper to describe our experience with a simplified one close penicillin treatment of chronic gonorrheal vaginitis. The results in 16 cases show that patients with this chronic disease need no longer be hospitalized but can be satisfactorily treated in the office and rapidly cured.

To conserve time and space, pertinent facts regarding our 16 cases are presented in tabular form.

COMMENT  Diagnosis was established by smear only if the case was clearcut and gram negative intracellular organisms were found in pus cells. In all other instances diagnosis was made both by smear and by culture. Most patients received sulfonamide and/or estrogen therapy for varying periods of time prior to institution of penicillin therapy. Sulfonamide therapy was discontinued either because of toxicity or of failure to respond.

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