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June 23, 1945


JAMA. 1945;128(8):589. doi:10.1001/jama.1945.92860250002009a

Intravenous injection of aminophylline in patients with intractable asthma has become recognized as an exceedingly valuable therapeutic remedy following its introduction in 1937.1 Since termination of bronchial spasm has been satisfactorily accomplished in more than 200 patients by rectal instillation of this drug, it has been repeatedly employed by nurses and by patients themselves in a program of bronchial relaxation.2 The relief of bronchial spasm takes place in ten to thirty minutes, more gradually than with intravenous injection, but the side effects on the circulation, such as dizziness and faintness, are rarely encountered and have in no instance been troublesome. Nausea and vomiting may take place after large doses, as in intravenous injection, but are much less apt to occur if the patient is in the reclining position for one hour after its administration. The intravenous ampule of 20 cc. containing 0.48 Gm. of the drug has been employed, but