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June 23, 1945

IMMUNIZATION WITH MULTIPLE ANTIGENS

JAMA. 1945;128(8):613. doi:10.1001/jama.1945.02860250059020

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Abstract

To the Editor:—  In Queries and Minor Notes in The Journal, May 5, the question was asked concerning the effectiveness and possible disadvantages of immunization with multiple antigens. The mixture in question consisted of cholera vaccine, typhus vaccine and triple typhoid vaccine. The two answers submitted agreed as to its effectiveness but did not point out a serious disadvantage inherent in such a procedure. I refer to its use in the egg-sensitive individual.At the Halloran General Hospital we have recently seen two Army nurses who gave a definite history of hypersensitiveness to eggs, on being questioned prior to inoculation with typhus vaccine. One gave a history of itching and swelling of the mouth and throat occurring after ingestion of one or two mouthfuls of soft boiled egg or of foods containing eggs. She could eat hard boiled eggs with impunity. The other gave a history of noting intensely itchy

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