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June 23, 1945


JAMA. 1945;128(8):614. doi:10.1001/jama.1945.02860250060023

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To the Editor:—  May I presume on your kindness to call to the attention of the members of the medical profession the difference between the term "whole blood" and "citrated blood," also called "modified blood."The term whole blood is used incorrectly so often when citrated blood is meant that it seems to me that this error should be corrected.Whole blood and citrated blood are as different as black and white. By far the most important life saving therapeutic agent we have today is properly matched whole blood, and it is my firm conviction that it is never going to be replaced by a substitute.Citrated blood is a substitute for whole blood, and it should be used only in emergencies and when it is not practical to use whole blood. Severe reactions following the use of citrated blood are far more frequent than when whole blood is used.

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