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January 2, 1937

PARA-AMINO-BENZENE-SULFONAMIDE AND ITS DERIVATIVES: EXPERIMENTAL AND CLINICAL OBSERVATIONS ON THEIR USE IN THE TREATMENT OF BETAHEMOLYTIC STREPTOCOCCIC INFECTION: A PRELIMINARY REPORT

Author Affiliations

Associate in Medicine and Fellow in Medicine, Respectively, the Johns Hopkins University Medical School BALTIMORE

From the Department of Medicine, the Johns Hopkins University Medical School.

JAMA. 1937;108(1):32-37. doi:10.1001/jama.1937.02780010034008
Abstract

The recent observations of numerous European investigators1 that para-amino-benzene-sulfonamide and certain of its chemical derivatives exert a specific chemotherapeutic effect in beta-hemolytic streptococcic infection are of great interest.

It will be our purpose in this preliminary communication to offer confirmatory observations to certain of the results already obtained by the aforementioned observers and to add new observations regarding the mode of action of these substances.

In the course of our investigations we have used two samples of para-amino-benzene-sulfonamide, one supplied to us by the Jackson Laboratory of E. I. DuPont de Nemours and Company, the other in tablet form under the name of "Prontylin" by the Winthrop Chemical Company. Two derivatives of para-amino-benzene-sulfonamide have also been studied. The first of these, the hydrochloride of 4'-sulfamido-2, 4 diaminoazo-benzene, was labeled "Prontosil tablets," while the second, the disodium salt of 4'-sulfamido-phenyl-2-azo-7-acetylamino-1 hydroxy naphthalene-3, 6-disulfonic acid, was sent to us in a

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