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June 30, 1945

SKIN GRAFTING IN HEMOPHILIA WITH A PREPARATION OF THROMBIN AND SULFANILAMIDE

JAMA. 1945;128(9):656-657. doi:10.1001/jama.1945.92860260001010
Abstract

Operative procedures on patients with hemophilia are not often undertaken because of the high postoperative mortality. Excessive bleeding following such a simple operation as tooth extraction has been a common cause of death.1 Recently the use of certain active thrombin preparations has made tooth extraction in hemophilia a relatively safe procedure.2 To our knowledge skin grafting has not been attempted in hemophilia, largely because of the likelihood of uncontrolled bleeding from the donor site.

The present report concerns a successful skin graft operation on a patient with hemophilia by means of a preparation of thrombin3 and sulfanilamide4 to control the bleeding from the donor site.

REPORT OF CASE  W. M., a white man aged 26, hemophilic, of Irish descent, was admitted for the fourteenth time on March 6, 1944.His previous admissions had been for bleeding from a cut lip, from the buccal mucosa, for epistaxes, for

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