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Comment & Response
August 13, 2019

Strategies to Adjust Positive End-Expiratory Pressure in Patients With ARDS

Author Affiliations
  • 1Department of Critical Care Medicine, Wuhan Union Hospital, Wuhan, China
JAMA. 2019;322(6):581. doi:10.1001/jama.2019.7876

To the Editor No benefit in death or days free from mechanical ventilation were reported with PES-guided PEEP titration vs an empirical high PEEP-Fio2 strategy in patients with moderate to severe ARDS. What was the racial/ethnic composition of the patients included in the 2 groups of the study,1 as significant racial/ethnic and sex differences in ARDS mortality exist in the United States?2,3 Also, significantly more men were in the PES-guided PEEP group than in the empirical high PEEP-Fio2 group (P = .01).