In Reply Dr Majer and colleagues point out the need to encompass heterogeneity of time horizons. We did not cover the topic of heterogeneity in our article,1 nor did we intend to say that all cohorts, for instance those with different starting ages, should have the same time horizon in a cost-effectiveness analysis. We had specifically pointed out that the appropriate time horizon should extend to cover all relevant benefits and harms of the interventions being evaluated.
Basu A, Maciejewski ML. Time Horizons in Cost Analyses—Reply. JAMA. 2019;322(6):582–583. doi:10.1001/jama.2019.7861
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