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January 9, 1937

CLASSIFICATION AND TREATMENT OF THE HEMORRHAGIC STATES: VALUE OF ROENTGEN IRRADIATION OF THE SPLEEN IN ESSENTIAL THROMBOCYTOPENIC PURPURA HAEMORRHAGICA

Author Affiliations

SAN FRANCISCO

From the Division of Medicine, University of California Medical School.

JAMA. 1937;108(2):83-86. doi:10.1001/jama.1937.02780020001001
Abstract

Werlhof1 first published his description of "morbus maculosus haemorrhagicus" in 1775, but knowledge concerning the nature of hemorrhagic disease has been slow in advancement. Since his publication, many attempts have been made to segregate various clinical types of purpura and to define their relationship to a defect in the clotting mechanism. Although efforts to explain the many etiologic factors concerned and the particular defect involved have not been entirely successful, certain aspects have been clarified by recent contributions to hematology. In view of the additional new facts, the present discussion will be devoted to a partial reclassification of the hemorrhagic disorders and to methods of treatment.

CLASSIFICATION OF THE HEMORRHAGIC STATES  Hornung2 in 1734 divided purpura into three groups: purpura simplex, febrile purpura, and purpura scorbutica. Since then from time to time various attempts have been made to subdivide purpura into clinical entities. Among these endeavors may be

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