Vitamin D3 supplementation did not lower the risk of type 2 diabetes in prediabetic adults, reported a trial in the New England Journal of Medicine.
The 2423 participants met at least 2 of 3 glycemic criteria for prediabetes and were randomized to receive 4000 IU per day of vitamin D3 or placebo. The majority of participants were vitamin D sufficient at baseline.
At 24 months, the mean serum 25-hydroxyvitamin D level in the vitamin D group increased from baseline and was higher than in the placebo group. After a median 2.5 years, diabetes occurred in 293 participants in the vitamin D group and 323 in the placebo group, suggesting vitamin D supplementation did not prevent progression to diabetes.
Slomski A. Vitamin D Doesn’t Protect Against Diabetes. JAMA. 2019;322(8):717. doi:10.1001/jama.2019.11564
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