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July 7, 1945


JAMA. 1945;128(10):729-731. doi:10.1001/jama.1945.92860270002010

Eosinophilic granuloma of bone was reported simultaneously in 1940 by Otani and Ehrlich1 and by Lichtenstein and Jaffe.2 Since then about 30 cases of this condition have been described.

Eosinophilic granuloma is a destructive bone lesion, which may be either single or multiple. It is characterized histologically by the presence of large mononuclear cell histiocytes and collections of eosinophils. The prognosis of the lesion is excellent.

ETIOLOGY  The cause of the condition is unknown. Trauma has been felt to be responsible by some; others have postulated a virus infection. The lesion is generally considered to be of an inflammatory nature, although all attempts to isolate an organism from the lesion have been unsuccessful.3Eosinophilic granuloma is seen most commonly in children and in young adults. Males are more frequently affected.

CLINICAL FEATURES  The symptomatology is referable primarily to the skeleton.4 The lesions are often solitary, involving the bones