In recent years attention has been called to a peculiar disease of the thyroid gland which is characterized by extensive lymphocytic infiltrations, marked reduction of the parenchyma and fibrosis. This disease, which occurs almost exclusively in women, starts insidiously and takes a very chronic course. The clinical manifestations are chiefly due to the pressure of the hardened gland on the trachea, and in the majority of the cases no symptoms of a disturbed thyroid function are encountered. The basal metabolic rate is often within normal range. In a few instances it is increased or diminished. After radical operation myxedema has been observed in about 40 per cent of the reported cases. Since the lymphocytic infiltrations frequently cause an enlargement of the gland, the disease has been classified among the goiters and the misleading adjective "lymphomatous" has been used. Hashimoto has been credited as being the first author to describe this
JAFFÉ RH. CHRONIC THYROIDITIS. JAMA. 1937;108(2):105–110. doi:https://doi.org/10.1001/jama.1937.02780020023008
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