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September 3, 2019

Compound in Broccoli Restores Tumor Suppressor Activity

JAMA. 2019;322(9):805-806. doi:10.1001/jama.2019.12367

A compound derived from cruciferous vegetables such as broccoli, brussels sprouts, and kale slowed tumor growth in laboratory animals, according to recent findings published in Science. The research also detailed the molecular pathway through which the compound mitigates tumorigenesis.

This work was born from an effort to identify regulators of the tumor suppressor PTEN (phosphatase and tensin homologue). This tumor suppressor is often dysregulated in human cancer cells through the loss of 1 gene copy, aberrant subcellular localization, or posttranslational modification.

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