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Research Letter
September 10, 2019

Prevalence of Oral HPV Infection in Unvaccinated Men and Women in the United States, 2009-2016

Author Affiliations
  • 1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland
  • 2The Ohio State University, Columbus
  • 3MD Anderson Cancer Center, Houston, Texas
  • 4Information Management Services Inc, Calverton, Maryland
JAMA. 2019;322(10):977-979. doi:10.1001/jama.2019.10508

Prophylactic human papillomavirus (HPV) vaccination has been recommended for routine use in US females since 2006 and males since 2011 for the prevention of anogenital HPV infections.1 Although studies have demonstrated high vaccine efficacy in reducing prevalence of oral HPV infection,2 prevention of oral HPV infections and oropharyngeal cancers is not a vaccine indication because of lack of randomized trials. Also lacking are surveillance studies for herd protection against oral HPV infections.3