With its narrow therapeutic range, warfarin is a tricky drug to use.
Dosing depends on many factors, including interactions with other medications, certain foods, or over-the-counter supplements. Outside of its therapeutic range, warfarin can increase the risk of bleeding or conversely of developing blood clots. Patients had been advised to avoid vitamin K–rich foods so as not to counteract warfarin’s effects, although clinical guidance now recommends consistent intake instead.
Voelker R. Green Vegetables, Herbs, and Oils May Help Stabilize Patients Taking Warfarin. JAMA. 2019;322(12):1128–1129. doi:10.1001/jama.2019.13060
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