The occurrence of extensive visceral hemorrhages in 2 patients with bacterial endocarditis treated by penicillin suggested this study.
REPORT OF CASES
Mrs. M. S., white, aged 37, entered St. Joseph Hospital May 5, 1944 because of intermittent chills and fever since November 1943, starting three weeks after the delivery of a normal child; weight loss of 20 pounds (9 Kg.) in six months; sudden onset of right hemiplegia on Jan. 30, 1944, which had improved considerably since its onset; moderate dyspnea, palpitation, and morning headaches. Physical examination showed pallor, emaciation, and evidence of an old right hemiplegia. The lungs were normal. The heart was slightly enlarged. There was a loud blowing systolic murmur over the mitral area. Serial blood cultures taken on admission showed hemolytic streptococci which developed in culture only after seven days. There was a moderate microcytic, hypochromic anemia. The white blood cells numbered 6,700 per
HINES LE, KESSLER DL. THE EFFECT OF PENICILLIN ON HEPARIN TOLERANCE. JAMA. 1945;128(11):794–796. doi:10.1001/jama.1945.02860280020006
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