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July 14, 1945

INTRA-ARTERIAL INJECTION OF PENICILLIN FOR INFECTIONS OF THE EXTREMITIES: PRELIMINARY REPORT

JAMA. 1945;128(11):796-802. doi:10.1001/jama.1945.02860280022007
Abstract

This report includes 24 cases treated for serious infections in the extremities. We present what we believe to be, the first series in which penicillin was administered by the intra-arterial route. The excellent results obtained are noteworthy. These findings assume added importance at this time because 70 per cent of war casualties are associated with wounds in the extremities. An even higher percentage of traumatic lesions of the extremities are observed in war industries. Since these injuries are frequently complicated by infection, a preliminary report on the utilization of penicillin by the arterial route would seem to be timely.

HISTORY  The history of intra-arterial therapy dates back to 1914. In this year Goyanes1 in Spain, Fiolle2 in France and Heddaus3 in Germany injected various drugs with more or less doubtful effect. A few years later, following the discovery of mercurochrome, occasional optimistic reports appeared in the literature.

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