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July 14, 1945

PRELIMINARY OBSERVATIONS OF THE GASTRIC MUCOSA IN PATIENTS WITH INFECTIOUS HEPATITIS

JAMA. 1945;128(11):803. doi:10.1001/jama.1945.92860280001008

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Abstract

In view of the prominence of anorexia, nausea, vomiting and upper abdominal pain in the clinical picture of infectious hepatitis, and because of the paucity of information concerning the pathology of this disease, it was deemed advisable to make observations with the gastroscope to determine whether abnormalities might be found which would throw light on the pathogenesis, symptomatology and pathology of this condition. Patients with infectious hepatitis were therefore examined with the aid of the Schindler flexible gastroscope on the day following admission, except, in 1 instance as noted. This report concerns 9 patients whose gastrointestinal symptoms were limited to their present illness. The clinical picture and laboratory findings of these patients were in complete accord with the diagnosis of infectious hepatitis. In every case the history indicated that the disease had been naturally transmitted and was not related to any preceding parenteral injection.

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