TRANSMISSION OF A SHOCK PRODUCING FACTOR
Shock is still one of the important causes of death of the injured soldier. While the symptoms and various physiologic responses of the shock syndrome are well known, the causative factors are still in doubt. One of the difficulties facing experiment in this field is the production of a reproducible shock syndrome. This has been accomplished to some extent by either traumatizing the leg of an experimental animal or by leaving a tourniquet on the leg for a time and then removing it. By using such a standardized technic Cannon and Bayliss concluded that there is a toxic substance emitted from the injured tissue which is responsible for the production of the general shock syndrome. Additional work has been attempted to show that a toxic agent is responsible for the initiation of shock. Recently Rapport, Guild and Canzanelli1 produced shock by allowing a
Current Comment. JAMA. 1945;128(11):813–814. doi:10.1001/jama.1945.02860280039012
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