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July 14, 1945

The Foetal Circulation and Cardiovascular System, and the Changes That They Undergo at Birth

JAMA. 1945;128(11):836. doi:10.1001/jama.1945.02860280062027

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Seven years ago Dr. A. E. Barclay, the dean of British roentgenologists, decided to tackle the problem of determining exactly what happens in the circulation when a placental animal is born; he wanted particularly to determine the time of functional closure of the ductus venosus. In order to facilitate this research, Dr. Barclay devised a cineradiographic apparatus and joined forces with Dr. Kenneth J. Franklin and Marjorie M. L. Prichard.

The book which describes their studies begins with a fine chapter on the history of the problem and what has been learned —mainly by the anatomists and embryologists. The next chapter is on the course of the blood flow in the fetal animal— mainly the lamb—as determined with the help of cineradiography and an opaque medium in the blood vessels. Chapter III reports a detailed study of the behavior of the many parts of the cardiovascular system in the mature

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