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January 16, 1937

Clinical Investigations into the Action of Protamine Insulinate

JAMA. 1937;108(3):231. doi:10.1001/jama.1937.02780030069029

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Krarup describes his studies on protamine insulin carried out during his appointment under Dr. H. C. Hagedorn at the Steno Memorial Hospital in Copenhagen from 1933 to 1935. Each one of the pages and of the charts bound with the text shows careful composition and the desire of the author to improve the treatment of diabetes. In The Journal, Jan. 18, 1936, an article by Hagedorn, Jensen, Krarup and Wodstrup gave the details of preparation of protamine insulin with a few illustrative charts showing its effect. In his monograph Krarup takes up in detail the clinical side of the picture and reports the results obtained in the first forty-one cases treated with various preparations. He precedes the description of the actual experiments with chapters on the clinical testing of medicaments with special reference to the condition obtaining in diabetes mellitus. He discusses the basis for the use of protamine insulin,

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