Twenty months ago the Department of Otolaryngology in the Medical School of Washington University decided to make a study of allergic rhinitis. The late Frank E. Ball of Muncie, Ind., created the Frank E. Ball Research Fund to carry out this study.
Antedating this research, two observations regarding ionization had already been made in the department. McMahon1 reported that ionization in dogs produced a fibrosis of the subepithelial tissue with marked hyperplastic bone changes; that the epithelial changes in the nose consisted of a primary destruction of cells with a later return to normal. The Alexanders2 reported that it was the patient who suffered from hay fever and had no reagins in the blood stream who was more likely to get a good result from ionization, while the one who had an abundance of reagins in the blood stream as a rule had an unsatisfactory result following the
DEAN LW, LINTON LD, SMIT HM, DEAN LW, MAHONEY C. THE TREATMENT OF ALLERGIC RHINITISWITH PARTICULAR REFERENCE TO IONIZATION AND THE CONTROL OF CHRONIC VASOMOTOR RHINITIS. JAMA. 1937;108(4):251–258. doi:10.1001/jama.1937.02780040001001
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