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July 28, 1945

TRANSMISSION EXPERIMENTS IN SERUM JAUNDICE AND INFECTIOUS HEPATITIS

JAMA. 1945;128(13):911-915. doi:10.1001/jama.1945.02860300001001
Abstract

In this paper we describe our experiences with the transmission of serum (or plasma) jaundice and infectious hepatitis. Actually these two conditions may be closely related in, that the former may represent the artificial production of the latter; but, while this may be true in some instances, it cannot yet be said that all serum jaundice belongs in this category. The etiologic agents in both of these conditions appear to be quite similar, and this holds for the clinical picture, which in both resembles "catarrhal jaundice." On the other hand there are differences which are poorly understood and can be best illustrated perhaps in terms of transmission experiments.

HOMOLOGOUS SERUM JAUNDICE  Homologous serum jaundice is not easy to define. It is produced by the parenteral inoculation of whole blood, serum or plasma, ordinarily obtained from an individual who is supposedly nonjaundiced, or at least from a donor not known (at

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