The hormone pregnancy test is based on the following facts:
The gonadotropic reactions of the ovary in infantile rodents:1 anterior pituitary reaction I, follicle ripening and induction of vaginal estrus; anterior pituitary reaction II, hyperemization of the ovary and follicle hemorrhage (blood dots); anterior pituitary reaction III, formation of corpora lutea.
The production and excretion in large amounts of gonadotropic hormone in pregnant women, monkeys and equines (but not in other mammals).2 Immediately after nidation of the egg in the endometrium, production of the gonadotropic hormones occurs explosively in such great quantities that even small amounts of blood or urine suffice to induce the aforementioned gonadotropic reactions. The hormone appears in lower concentrations in the blood than in the urine.
APPLICATION OF THE ORDINARY HORMONE PREGNANCY TEST AND ITS MODIFICATIONS
ZONDEK B, SULMAN F, BLACK R. THE HYPEREMIA EFFECT OF GONADOTROPINS ON THE OVARY: AND ITS USE IN A RAPID PREGNANCY TEST. JAMA. 1945;128(13):939–944. doi:10.1001/jama.1945.02860300029006
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