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July 28, 1945

THE PREPARATION OF POTENT ANTI-RH TYPING SERUMS BY INJECTION OF RH POSITIVE BLOOD INTO PREVIOUSLY ISOIMMUNIZED INDIVIDUALS

JAMA. 1945;128(13):944-946. doi:10.1001/jama.1945.92860300001007
Abstract

The experience of the William Buchanan Blood, Plasma and Serum Center with routine Rh typing since May 1944 has led to the conviction that this additional routine service is essential for transfusions of maximum safety.1 It also appears that infant mortality due to hemolytic disease of the newborn (erythroblastosis fetalis) can be decreased through the additional information acquired from routine Rh typing of all obstetric cases and newborn infants; also routine Rh typing should be available to military services, first, because in the great number of whole blood transfusions now being given there is increased opportunity for Rh negative individuals to be sensitized so that later transfusions may be dangerous and, second, the necessity for multiple transfusions following severe battle injuries increases the opportunities for isoimmunization with the Rh antigen and resultant transfusion accidents.

The chief problem in routine Rh typing is to secure a sufficient and continuing source of potent

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