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July 28, 1945

PREVENTION OF UNINTENTIONAL ISOIMMUNIZATION OF THE RH NEGATIVE FEMALE POPULATION

JAMA. 1945;128(13):946. doi:10.1001/jama.1945.92860300003007a
Abstract

The obstetric history of mothers of erythroblastotic infants reveals that this condition, as a rule, does not occur in the first born. Frequently the first one, two or more Rh + infants are normal. From the point of view of isoimmunization, it is clear that oneor more pregnancies with Rh + offspring are required to induce a state of isoimmunization sufficiently intense to produce the hemolytic condition in the following Rh + infant.1 In other words, the first one or more pregnancies serve the same preparatoryfunction as repeated uneventful transfusions of an Rh − male patient with Rh + blood.

The study to be presented indicates the importance of prevention of the deliberate isoimmunization of the Rh − female population, including even the newborn infant, by transfusions with Rh + blood.2 Evidence is produced to indicate that even the first born is frequently lost as a result of

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