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July 28, 1945


JAMA. 1945;128(13):954. doi:10.1001/jama.1945.02860300044010

Radioactive phosphorus has now been employed experimentally in treatment for about six years. The earlier work on this subject has been previously discussed in these columns.1 Now a fairly extensive experience with this form of therapy has accumulated, especially for the leukemias and polycythemia vera. Recently Warren2 reported results in the third large group of patients treated by this means since 1940 with radioactive phosphorus, consisting of 81 cases of leukemia, myeloma, Hodgkin's disease and polycythemia vera. The radioactive phosphorus employed in his series was prepared either by bombardment by the cyclotron of red phosphorus placed in an external target chamber or by the bombardment of an iron phosphide probe placed in the deuteron stream of the cyclotron just inside the port. Most of the cases of leukemia subjected to treatment had failed to respond to or were known to be refractory to prior roentgen therapy. Some of