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July 28, 1945

Current Comment

JAMA. 1945;128(13):956-957. doi:10.1001/jama.1945.02860300046013

THE ANTIRETICULAR CYTOTOXIC SERUM OF BOGOMOLETS IN THE TREATMENT OF RHEUMATISM  The therapeutic agent called the antireticular cytotoxic serum of Bogomolets (A C S) is based on the concept that the connective tissue of an organism contains a number of hitherto uninvestigated physiologic functions. The aim of the serum is to stimulate these functions and to intensify active immunity. The serum is produced by the immunization of horses with the cells of the spleen and bone marrow taken from a human corpse. The determination of the amount of cytotoxins in the serum obtained is important. The amount of cytotoxins in the serum of the immunized animal can be determined by applying a modification of the reaction of complement fixation (reaction of Bordet-Gengou); that is, by using an antigen for the reaction of complement fixation,