In this issue of JAMA, the US Preventive Services Task Force (USPSTF) has published updated guidelines for screening for asymptomatic bacteriuria in adults1 along with an updated evidence report and systematic review.2 These recommendations are not substantively changed from the previous recommendations, published in 2008.3 Screening for bacteriuria or antimicrobial treatment for asymptomatic bacteriuria is not recommended for healthy nonpregnant women or healthy men (D recommendation). Screening with a urine culture collected at 12 to 16 weeks of gestation or at the first prenatal visit is recommended for pregnant women, with antimicrobial treatment if asymptomatic bacteriuria is present (B recommendation). These recommendations are consistent with other recent guidelines that have addressed screening and treatment of asymptomatic bacteriuria for these populations.4,5