In Reply Drs Cristea and Gentili raise some useful considerations related to our research letter.1 Our work addressed a single potential source of publication bias: how do RCTs that accept or reject a null hypothesis for the primary outcome compare on simple publicly available measures of “high impact”? Finding no difference between these postpublication metrics should not be read as an obviation of publication biases more generally.
Heathers JA, Nagata JM, Murray SB. Publication Bias in Trials With and Without Null Findings—Reply. JAMA. 2019;322(12):1214. doi:10.1001/jama.2019.11144
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