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August 4, 1945


JAMA. 1945;128(14):1020-1022. doi:10.1001/jama.1945.92860310001009

Kala-azar (visceral leishmaniasis) is an infectious disease resembling clinically in many respects chronic malaria and undulant fever. It is characteristically associated with an irregular, recurring fever over a period of weeks, sometimes having a double daily rise, progressive enlargement of the spleen, followed by hepatomegaly, and usually later in the course of the disease anemia, leukopenia and progressive wasting. According to Manson-Bahr1 the disease may vary a great deal in its onset. As stated in the beginning, it may be characterized by a chronicity simulating other prolonged recurring infectious diseases. On the other hand, in a small percentage of cases it may be characterized by a latency without symptoms and present its activity by an acute onset with