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In This Issue of JAMA
October 8, 2019


JAMA. 2019;322(14):1329-1331. doi:10.1001/jama.2018.15542

Articular cartilage loss is a measure of structural disease progression in osteoarthritis. Hochberg and colleagues randomized 549 participants with symptomatic radiographic knee osteoarthritis and found that intra-articular sprifermin improved total femorotibial joint cartilage thickness after 2 years.

Visual Abstract and CME

Studies of self-management support for outpatients with chronic obstructive pulmonary disease (COPD) have demonstrated improvements in health-related quality of life and reductions in COPD-related acute care events. Aboumatar and colleagues randomized 240 hospital patients with COPD and found that a 3-month program of support for transition and long-term self-management resulted in significantly greater COPD-related hospitalizations and emergency department visits, without improvement in quality of life. In an Editorial, Rinne and colleagues suggest that safe interventions are still needed to prevent COPD hospitalizations.

Editorial and Editor’s Note


The benefits of reductions in systolic blood pressure and low-density lipoprotein cholesterol may be cumulative. Ference and colleagues analyzed data for 438 952 participants and found that lifelong genetic exposure to lower levels of systolic blood pressure and low-density lipoprotein cholesterol were associated with lower cardiovascular risk.

Author Audio Interview

Surgical evacuation of hematoma is a standard treatment for patients with intracerebral hemorrhage. Kuramatsu and colleagues analyzed data for 578 patients with cerebellar intracerebral hemorrhage and found that surgical hematoma evacuation, compared with conservative treatment, was not associated with improved functional outcome. In an Editorial, Hemphill and Amin-Hanjani recommend further research to identify patients with brain tissue viability who may benefit from surgical intervention.


Clinical Review & Education

This JAMA Diagnostic Test Interpretation article by O’Brien and Sacks presents a 57-year-old man who was noted at his initial primary care visit to have risk factors for diabetes. What would you do next?

The use of repellents is recommended by the Centers for Disease Control and Prevention and the Environmental Protection Agency to prevent infections transmitted by mosquitoes and ticks. This Medical Letter on Drugs and Therapeutics discusses the efficacy and safety of topical insect and tick repellents.