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August 4, 1945

DENGUE VACCINE

JAMA. 1945;128(14):1026-1027. doi:10.1001/jama.1945.02860310040013
Abstract

Thanks to the heroic cooperation of inmates of the New Jersey State Prison, who volunteered without offer of reward to serve as subjects for numerous inoculations with virus, Sabin and his associates1 of the Army Epidemiological Board announce the development of a promising new vaccine for dengue fever.

In 1928 Manoussakis2 found that dengue virus (infective human serum) which had lost its pathogenicity as a result of irradiation, heating or prolonged storage would not protect nonimmune human beings against subsequent inoculation with fully virulent dengue virus. He concluded that inoculation with a nonviable dengue vaccine was without promise as a prophylactic measure. Blanc and his associates3 of the Hellenic Pasteur Institute subsequently found that repeated vaccination with a dengue vaccine (infectious serum) attenuated by the addition of 5 to 8 per cent bile confers an effective immunity. The virus-bile mixture, however, lost all traces of its immunizing

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