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Research Letter
October 15, 2019

Association of Maternal Gastric Bypass Surgery With Offspring Birth Defects

Author Affiliations
  • 1Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden
  • 2Department of Surgery, Örebro University, Örebro, Sweden
JAMA. 2019;322(15):1515-1517. doi:10.1001/jama.2019.12925

Maternal body mass index (BMI) and glucose control are associated with offspring birth defects.1,2 Bariatric surgery results in weight loss and glucose normalization but is also associated with nutritional deficiencies and substance abuse,3 which could cause birth defects as hypothesized based on case series.4