Group O blood has been used extensively as universal blood. Carefully investigated reactions to group O blood, published by workers with extensive experience in the field of blood transfusion, have caused many physicians to object to this method as a general procedure, granting that the Rh factor is given proper consideration as a source of reactions. It is reasonable to assume that isoagglutinins introduced into the circulation of human beings harboring the corresponding agglutinogens in the cells and plasma should combine with both, and it is a surprising fact that damaging reactions are not observed more frequently. Aubert, Boorman and Dodd1 have demonstrated the occurrence of intravascular agglutination and hemolysis in a significant percentage of cases following the transfusion of serum of group O into recipients belonging to group A. On the basis of such observations the indiscriminate use of universal blood for transfusions into patients of different blood
KLENDSHOJ NC, WITEBSKY E. TRANSFUSION OF O BLOOD: CONDITIONED BY THE ADDITION OF BLOOD GROUP SPECIFIC SUBSTANCES FURTHER CLINICAL INVESTIGATIONS. JAMA. 1945;128(15):1091–1093. doi:10.1001/jama.1945.02860320033009
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