Our first clinical experience with privine hydrochloride intranasally in allergic and infectious rhinitis gave us the impression that it was the most effective vasoconstrictor available. The continued use of this drug in our practice, however, began to give us increasing evidence that in addition to its vasoconstrictor action there was a congestive phase. In the last year or so we have been impressed with the large number of patients in whom symptoms of nasal congestion have been aggravated or prolonged by the continued use of privine.
We have seen at least 75 patients, with additional numbers being added every week, whose nasal congestion has been aggravated or maintained by privine. The usual course of events is as follows: The patient having hay fever or perennial allergic rhinitis begins to use privine for relief. Occasionally this start of the continued use of the drug may have its origin in the attempt
Samuel M. Feinberg, Stdney Friedlaender. NASAL CONGESTION FROM FREQUENT USE OF PRIVINE HYDROCHLORIDE. JAMA. 1945;128(15):1095–1096. doi:10.1001/jama.1945.92860320001011