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The monograph by Professor Hirsch deals with the author's theory of the mode of action of penicillin, the manometric test of penicillin activity developed by him and with a method of growing crude penicillin. Hirsch demonstrated in his experiments in vitro that penicillin has neither bactericidal nor bacteriostatic effect. Penicillin was shown to exert an effect only in bacterial cultures capable of multiplying. This effect becomes evident after multiplication of the bacteria has progressed for some time. In proportion to the added concentration of penicillin, the multiplication sooner or later suddenly changes into a logarithmically progressing process of destruction which may lead to lysis of the staphylococci. Generation of cells which develops in the presence of penicillin is incapable of further multiplication and their individual life span is abnormally short. These staphylococci show the morphologic changes described by Gardner. This effect of penicillin on the staphylococcus culture is a qualitative
Penicillin hakkinda in vitșo arastirmalar I-III (Almanca bölüm). Penicillin-Studien in Vitro I-III. JAMA. 1945;128(15):1131. doi:10.1001/jama.1945.02860320073032
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