Opioid pain medications are frequently used to treat acute and chronic pain and have had a major increase in use over the last 2 decades, particularly for noncancer pain. In 2017, there were 58 opioid prescriptions written for every 100 people in the United States. An estimated 17% of the US population has had at least 1 opioid prescription filled, although there is some uncertainty about this estimate because of illicit and nonprescription use.1