Because of the long period of convalescence following infectious hepatitis with resulting loss of manpower to the United States Army, the present study was conducted in suitable groups in the Mediterranean Theater of Operations in order to determine whether or not gamma globulin is an effective therapeutic agent in lessening the severity of the disease and in shortening the period of convalescence. Stokes and Neefe,1 pointing out that globulin is often of value if injected soon after the onset of the initial symptoms of measles,2 suggested its trial as a therapeutic measure in early infectious hepatitis.
Through the cooperation of an air force in this theater, patients developing infectious hepatitis were made available for the study. The majority of the patients came from one bombardment group and were diagnosed by the squadron physicians, who had extensive experience with the disease. Patients were chosen for the study as soon
GELLIS SS, STOKES J, FORSTER HW, BROTHER GM, HALL WM. THE USE OF HUMAN IMMUNE SERUM GLOBULIN (GAMMA GLOBULIN): IN INFECTIOUS (EPIDEMIC) HEPATITIS IN THE MEDITERRANEAN THEATER OF OPERATIONS II. STUDIES ON TREATMENT IN AN EPIDEMIC OF INFECTIOUS HEPATITIS. JAMA. 1945;128(16):1158–1159. doi:10.1001/jama.1945.02860330026007
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