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August 18, 1945

Penicillin and Other Antibiotic Agents

JAMA. 1945;128(16):1193. doi:10.1001/jama.1945.02860330061029

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Abstract

A noteworthy accomplishment of the war effort in relation to medicine has been the development of antibiotic therapy. This applies especially to penicillin. Although the advances have been phenomenal, adequate information concerning the therapeutic indications of penicillin has been made available to the medical profession, as well as other pertinent knowledge. Nevertheless in such a rapidly developing field a crystallization of the subject in the form of a monograph is desirable, with the realization, however, that such an effort may be superseded in the near future by information not available at present.

Herrell has endeavored to summarize the extensive fundamental and clinical studies on penicillin and other antibiotic agents. The first hundred pages are devoted to the basic investigations on penicillin. This includes a historical survey; methods of preparation; its physical, chemical and antibacterial properties; absorption, diffusion and excretion, and assay methods. Precise information concerning the chemistry of penicillin is

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