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August 25, 1945

THE TREATMENT OF PNEUMONIA WITH SULFONAMIDES AND PENICILLIN

JAMA. 1945;128(17):1219-1224. doi:10.1001/jama.1945.02860340025006
Abstract

Until recently papers devoted to penicillin therapy have consisted largely of descriptions of the results obtained with this new chemotherapeutic agent, and the interest with which the reports were studied was enhanced by the great scarcity of the antibiotic. Now, however, we are reaching the point at which most descriptions of therapeutic triumphs are merely repetitious rather than informative. The important objective now is to become familiar with the limitations of our new weapon, to gage its usefulness in comparison with the agents it is replacing and to determine the optimal dosage and mode of administration for various diseases. Our purpose in this report is to consider these factors in relation to one of the diseases for which penicillin is most widely used, namely pneumonia.

Of the pathogenic organisms sensitive to penicillin, one of the most susceptible is the pneumococcus. In vitro its growth is completely inhibited by as little

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