Not long ago, vitamin D was riding high. Beyond its role in calcium homeostasis and bone health, animal studies linked vitamin D deficiency to numerous chronic illnesses including hypertension, diabetes, autoimmunity, and malignancy.1 Corroborating human observational studies reported associations between vitamin D deficiency and increased risks of hypertension, diabetes, cardiovascular disease, autoimmunity, and cancer.2 The lay press seized on this chorus of observational studies, testing of serum 25-hydroxyvitamin D levels proliferated, and supplementation with cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) increased substantially.3
Lucas A, Wolf M. Vitamin D and Health Outcomes: Then Came the Randomized Clinical Trials. JAMA. 2019;322(19):1866–1868. doi:https://doi.org/10.1001/jama.2019.17302
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