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Editorial
November 8, 2019

Vitamin D and Health Outcomes: Then Came the Randomized Clinical Trials

Author Affiliations
  • 1Division of Nephrology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina
  • 2Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina
JAMA. 2019;322(19):1866-1868. doi:10.1001/jama.2019.17302

Not long ago, vitamin D was riding high. Beyond its role in calcium homeostasis and bone health, animal studies linked vitamin D deficiency to numerous chronic illnesses including hypertension, diabetes, autoimmunity, and malignancy.1 Corroborating human observational studies reported associations between vitamin D deficiency and increased risks of hypertension, diabetes, cardiovascular disease, autoimmunity, and cancer.2 The lay press seized on this chorus of observational studies, testing of serum 25-hydroxyvitamin D levels proliferated, and supplementation with cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) increased substantially.3

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